Evaluating multi-bug point-of-care tests for diagnosing STIs

New point-of-care (POC) tests are currently being developed which can be used in clinic to simultaneously test for multiple sexually transmitted infections (STIs). In work now published online in BMJ Open, we developed a model to compare three possible strategies for POC STI testing with the current practice of microscopy and lab-based testing. The three strategies were: 1) a dual test for chlamydia and gonorrhoea; 2) a triple test which also tests for M. genitalium, and 3) a quadruple test which also tested for trichomoniasis. The model examined the overall costs, patient benefits and cost-effectiveness of these strategies. The full results of the economic evaluation including the article and supplementary material are available online.

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The NHS wastes more than £7 billion because it’s slow to use new diagnostics

An article authored by Aquarius was published today on the British In Vitro Diagnostics Association (BIVDA) website. The article commissioned jointly by BIVDA and Innovate UK suggests that the NHS could save over £6.9 billion in 5 years by making better use of diagnostic tests already on the market. These savings could have a huge impact in reducing the annual NHS shortfall, which is expected to be £20 billion by 2022.

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Assessing the impact of point-of-care testing for influenza and RSV in children admitted to hospital

The winter flu season brings added pressure to emergency and acute hospital services. In the UK, children and infants account for more than a third of flu related hospital admissions since flu and respiratory syncytial viruses (RSV) can be particularly severe in children, particularly those with existing conditions such as asthma.

In our recent paper published, we report the results of a real-world evaluation conducted in a busy children’s hospital in central London. We assessed the impact and economic benefits of using a 90-minute point-of-care (POC) assay to test for influenza and RSV in children and infants admitted to hospital. This was done by comparing data collected from an acute paediatric ward during one flu season, when standard laboratory testing was used, with data collected from the same ward in the subsequent flu season, when the POC test was in use.

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PRESS RELEASE: Aquarius Population Health wins a prestigious SBRI grant from Innovate UK

Work has begun to develop a digital value proposition tool for a novel rapid sexually transmitted infection (STI) test

London, UK, 14 August 2017

Aquarius Population Health, a leading independent health economics consultancy, has recently been awarded an 18-month Innovate UK grant in collaboration with Atlas Genetics Ltd and the Applied Diagnostic Research and Evaluation Unit at St George’s University of London (total £2,000,000). The funding will be used to develop evidence for health services to support the introduction of a new rapid diagnostic test. In 30-minutes the test can diagnose multiple sexually transmitted infections including chlamydia and gonorrhoea – infections which could take up to a week to diagnose using the current laboratory testing systems.

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Evaluating the use AMR POCT in treatment of gonorrhoea

Aquarius Population Health recently worked with the Applied Diagnostic Research & Evaluation Unit (ADREU) at St. Georges, University of London, to assess the cost-effectiveness of six hypothetical strategies for using antimicrobial resistance point-of-care testing to guide the treatment of gonorrhoea.  Our findings were presented at the STI & HIV World Congress in Rio de Janeiro, Brazil. [Wednesday 12th July, Session 15: STI/HIV testing and management].

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Evaluating multi-bug point-of-care tests for sexually transmitted infections

We were a collaborator on a recent Innovate UK-funded SBRI project with Atlas Genetics and the Applied Diagnostic Research and Evaluation Unit at St George’s University of London. In this project, our team compared the overall costs, patient benefits and cost-effectiveness of three different multi-pathogen point-of-care testing strategies with the current strategy of microscopy and lab-based testing.

This work was presented at the STI and HIV World Congress which takes place July 9-12 in Rio de Janeiro. The poster can be seen here.

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Integrating Personalised Medicine into the NHS

Personalised medicine is an emerging field that brings exciting changes to patient care. So, what exactly is personalised medicine and what are its benefits?

In the past, various terms have been used interchangeably: ‘stratified medicine’, ‘personalised medicine’ and ‘precision medicine’. These terms refer to data driven medicine, in which data can be a patient’s genetic makeup, molecular data or disposition to respond to therapy. These data allow for a targeted approach to prevention, diagnosis and treatment using technologies such as genomic medicine, diagnostic tests, predictive data analytics or real-time patient monitoring.

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Antimicrobial resistance point-of-care test for gonorrhoea

In a study commissioned by the Review on Antimicrobial Resistance, Aquarius Population Health worked with modellers at the University of Bristol to create a mathematical model. The model was used to assess the economic implications and treatment impact of introducing a hypothetical antimicrobial resistance (AMR) point-of-care test (POCT) for gonorrhoea. Results of the study were published this week in BMJ Open.

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Antimicrobial Resistance: Innovation in rapid diagnostics

Part 3: What role does innovation such as rapid diagnostics have in preventing AMR?

Just as new technology has helped us in the fight against global warming (fuel efficiency, clean energy etc.), technology can also help us in the fight against antimicrobial resistance (AMR). One such area is rapid diagnostics – identified as a key intervention for reducing AMR in the government’s 2016 Review of Antimicrobial Resistance.

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Where are we with HIV in the UK?

HIV has profoundly impacted public health. Currently, 36.7 million people live with HIV worldwide and over 100,000 in the UK. According to data from Public Health England (PHE),  an estimated 6,000 people were newly diagnosed with HIV in the UK in 2015 and 13,500 people not yet diagnosed.

Increasing awareness, swift diagnosis and provision of antiretroviral therapy for people who are diagnosed is crucial to prevent onward transmission of HIV and end the HIV epidemic.  These aims were highlighted in the United Nations Programme on HIV and AIDS (UNAIDS) 90-90-90 global target and the latest World Health Organization (WHO) recommendations on HIV treatment and prevention.

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